What is the most effective antioxidant against ulcers? An experimental study

Background: The aim of this study was to evaluate the effects of selenium, gingko biloba, melatonin and vitamin E, which are antioxidants in the prevention of ulcerative lesions occurring in rats exposed to immobility and cold stress by using comparative histochemical and statistical methods. Material and Methods: 6 groups were created with 42 Wistar albino rats; control, ulcer (performed by immobilization and cold stress), selenium (0.5 ml/kg), Gingko biloba (300 mg/kg), melatonin (60 mg/kg), vitamin E (60 mg/kg). Gastric tissues were taken and examined by histochemical methods. Statistical methods were used to determined gastric pit and glands leight. Results: In the ulcer group; expansive degenerative changes was seen in gastric mucosa and lots of different types necrotic areas were seen. In the vitamin E administered group, similar findings with the control group were observed except the superficial mucosal epithelium spilth in the located area and moderate dilatation in gastric glands. With the alcian blue dying to observe the mucus compared with other groups, the most evident increase in mucus was found in this group. Conclusions: In the histochemical and statistical evaluations we considered that prevention of the formation the gastric lesions in case of stress, vitamin E was the most effective agent.